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Douglas R. Green

Researcher at St. Jude Children's Research Hospital

Publications -  699
Citations -  163496

Douglas R. Green is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 182, co-authored 661 publications receiving 145944 citations. Previous affiliations of Douglas R. Green include La Jolla Institute for Allergy and Immunology & St. Jude Medical.

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Journal ArticleDOI

Mitochondria and apoptosis

Douglas R. Green, +1 more
- 28 Aug 1998 - 
TL;DR: A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

Ruth M. Kluck, +3 more
- 21 Feb 1997 - 
TL;DR: In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases, leading to fodrin cleavage and apoptotic nuclear morphology, and Bcl-2 acts to inhibit cy tochrome c translocation, thereby blocking caspase activation and the apoptotic process.
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Lorenzo Galluzzi, +186 more
- 23 Jan 2018 - 
TL;DR: The Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
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The Pathophysiology of Mitochondrial Cell Death

Douglas R. Green, +1 more
- 30 Jul 2004 - 
TL;DR: The therapeutic induction of MOMP may restore apoptosis in cancer cells in which it is disabled, and the general rules governing the pathophysiology and controversial issues regarding its regulation are discussed.