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Katie R. Martin

Researcher at Van Andel Institute

Publications -  30
Citations -  7404

Katie R. Martin is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Autophagy & Lysosome. The author has an hindex of 19, co-authored 26 publications receiving 5908 citations. Previous affiliations of Katie R. Martin include University of Utah & Michigan State University.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

The genomic landscape of tuberous sclerosis complex.

Katie R. Martin, +18 more
- 15 Jun 2017 - 
TL;DR: It is determined that TSC lesions contain a low somatic mutational burden relative to carcinomas, a subset feature large-scale chromosomal aberrations, and highly conserved molecular signatures for each type exist.
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A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress

Katie R. Martin, +9 more
- 26 Oct 2018 - 
TL;DR: Two small molecule ULK1 inhibitors are reported, ULK-100 andULK-101, and superior potency and selectivity over a noteworthy published inhibitor are established, and it is demonstrated that ULK 1 inhibition sensitizes KRAS mutant lung cancer cells to nutrient stress.
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Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib

Megan L. Goodall, +7 more
- 17 Apr 2014 - 
TL;DR: It is determined that both inhibitors function through lysosomal deacidification mechanisms and ultimately disrupt autophagosome turnover, providing a means to effectively block autophagy and have the potential to sensitize mutant BRAF melanomas to first-line therapies.