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Ioannis P. Trougakos

Researcher at National and Kapodistrian University of Athens

Publications -  211
Citations -  13327

Ioannis P. Trougakos is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 39, co-authored 175 publications receiving 10224 citations. Previous affiliations of Ioannis P. Trougakos include University of British Columbia & European University Cyprus.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Clusterin/apolipoprotein J in human aging and cancer.

Ioannis P. Trougakos, +1 more
- 01 Nov 2002 - 
TL;DR: The role of ApoJ during cellular senescence and tumorigenesis is discussed, especially under the light of the recently demonstrated variousApoJ intracellular protein forms and their interaction with molecules involved in signal transduction and DNA repair, raising the possibility that its overexpression during cellularsenescence might cause a predisposition to cancer.
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Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

Niki Chondrogianni, +5 more
- 25 Jul 2003 - 
TL;DR: In this article, the role of the proteasome during cellular senescence and survival has been investigated using WI38 fibroblasts as a model for cellular senocyte growth arrest, where the authors observed reduced levels of proteasomal peptidase activities coupled with increased levels of both oxidized and ubiquitinated proteins in senescent cells.
Journal Article

Central role of the proteasome in senescence and survival of human fibroblasts

Niki Chondrogianni, +5 more
- 01 Jan 2003 - 
TL;DR: Partial inhibition of proteasomes in young cells caused by treatment with specific inhibitors induced a senescence-like phenotype, thus demonstrating the fundamental importance of the proteasome for retaining cellular maintenance and homeostasis and providing insights toward a better understanding of proteAsome regulation.