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Carlos Guillén

Researcher at Complutense University of Madrid

Publications -  37
Citations -  7297

Carlos Guillén is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Autophagy & Insulin resistance. The author has an hindex of 17, co-authored 33 publications receiving 5808 citations. Previous affiliations of Carlos Guillén include Carlos III Health Institute & Hospital Clínico San Carlos.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Pancreatic β-Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

Alberto Bartolomé, +14 more
- 01 Sep 2014 - 
TL;DR: Evidence of β-cell autophagy impairment is provided as a link between mTORC1 hyperactivation and mitochondrial dysfunction that probably contributes to β- cell failure.
Journal ArticleDOI

Autophagy Plays a Protective Role in Endoplasmic Reticulum Stress-Mediated Pancreatic β Cell Death

Alberto Bartolomé, +2 more
- 05 Sep 2012 - 
TL;DR: It is shown how the autophagic response plays a prosurvival role in β cells may be contributing to ER stress-mediated cell death, and in this regard, rapamycin treatment increased both autophagy and cell survival under ER stress.
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MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.

Alberto Bartolomé, +8 more
- 13 Nov 2017 - 
TL;DR: Data prove the necessity of intact MTORC1 signaling to regulate two synergistic processes required for clearance of damaged mitochondria: (i) general autophagy initiation and (ii) PINK1/PARK2-mediated selective targeting of uncoupled mitochondria to the autophagic machinery.