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Aparna Lakkaraju

Researcher at University of California, San Francisco

Publications -  44
Citations -  8275

Aparna Lakkaraju is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Retinal pigment epithelium & Macular degeneration. The author has an hindex of 21, co-authored 41 publications receiving 6635 citations. Previous affiliations of Aparna Lakkaraju include University of Wisconsin-Madison & Wisconsin Alumni Research Foundation.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Itinerant exosomes: emerging roles in cell and tissue polarity

Aparna Lakkaraju, +1 more
- 01 May 2008 - 
TL;DR: New evidence is discussed suggesting that exosomes participate in the transport of morphogens and RNA, and thus influence cell polarity and developmental patterning of tissues.
Journal ArticleDOI

The cell biology of the retinal pigment epithelium.

Aparna Lakkaraju, +6 more
- 24 Feb 2020 - 
TL;DR: The retinal pigment epithelium, a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function.
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The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells

Aparna Lakkaraju, +2 more
- 26 Jun 2007 - 
TL;DR: It is shown that A2E, a quaternary amine and retinoid by-product of the visual cycle, causes the accumulation of free and esterified cholesterol in RPE cells, and the mechanism involves neither generalized alterations in late endosomal/lysosomal pH nor a direct inhibition of acid lipase activity.