scispace - formally typeset
V

Valentina Cianfanelli

Researcher at University of Rome Tor Vergata

Publications -  39
Citations -  8817

Valentina Cianfanelli is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Autophagy & Mitophagy. The author has an hindex of 21, co-authored 39 publications receiving 7000 citations. Previous affiliations of Valentina Cianfanelli include Boston Children's Hospital.

Papers
More filters
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

Francesca Nazio, +10 more
- 01 Apr 2013 - 
TL;DR: As ULK1 has been shown to activate AMBRA1 by phosphorylation, the proposed pathway may act as a positive regulation loop, which may be targeted in human disorders linked to impaired autophagy.
Journal ArticleDOI

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

Flavie Strappazzon, +10 more
- 01 Mar 2015 - 
TL;DR: It is shown that, upon mitophagy induction, AMBRA1 binds the autophagosome adapter LC3 through a LIR (LC3 interacting region) motif, this interaction being crucial for regulating both canonical PARKIN-dependent and -independent mitochondrial clearance.
Journal ArticleDOI

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications.

Francesca Nazio, +7 more
- 06 Feb 2019 - 
TL;DR: A comprehensive view of how and by which regulatory molecules these two processes drive cell fate is missed, and novel viewpoints on possible therapeutic strategies, based on the modulation of these degradative systems, are offered.