Guido R.Y. De Meyer

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is demonstrated that phagocytosis of ACs is impaired in atherosclerotic plaques, which is at least partly attributed to oxidative stress and cytoplasmic saturation with indigestible material.

TL;DR: It is concluded that SMCs within human fatty streaks express BAX, which increases the susceptibility of these cells to undergo apoptosis, which could be important in the understanding of the transition of fatty streaks into atherosclerotic plaques, which are characterized by regions of cell death.

TL;DR: Evidence is provided that oxidative DNA damage and repair increase significantly in human atherosclerotic plaques and this is accompanied by the upregulation of DNA repair mechanisms.