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Christian Frezza

Researcher at University of Cambridge

Publications -  178
Citations -  29817

Christian Frezza is an academic researcher from University of Cambridge. The author has contributed to research in topics: Mitochondrion & Cancer. The author has an hindex of 60, co-authored 156 publications receiving 23589 citations. Previous affiliations of Christian Frezza include University of Cologne & University of Glasgow.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, +32 more
- 11 Apr 2013 - 
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

Edward T. Chouchani, +29 more
- 20 Nov 2014 - 
TL;DR: In this article, a comparative in vivo metabolomic analysis was conducted to identify widely conserved metabolic pathways responsible for mitochondrial reactive oxygen species (ROS) production during ischaemia reperfusion.
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OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

Christian Frezza, +10 more
- 14 Jul 2006 - 
TL;DR: Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.
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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Evanna L. Mills, +22 more
- 06 Oct 2016 - 
TL;DR: It is demonstrated that upon lipopolysaccharide stimulation, macrophages shift from producing ATP by oxidative phosphorylation to glycolysis while also increasing succinate levels, and repurpose mitochondria from ATP synthesis to ROS production in order to promote a pro-inflammatory state.