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Steven K. Backues

Researcher at Eastern Michigan University

Publications -  18
Citations -  6023

Steven K. Backues is an academic researcher from Eastern Michigan University. The author has contributed to research in topics: Autophagy & Autophagosome. The author has an hindex of 12, co-authored 16 publications receiving 4171 citations. Previous affiliations of Steven K. Backues include University of Michigan.

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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Ume6 transcription factor is part of a signaling cascade that regulates autophagy.

TL;DR: A negative regulator of ATG8 transcription, Ume6, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels is identified, indicating that this process is highly conserved.
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Rph1/KDM4 Mediates Nutrient-Limitation Signaling that Leads to the Transcriptional Induction of Autophagy

TL;DR: Rph1 maintains autophagy at a low level in nutrient-rich conditions; upon nutrient limitation, the inhibition of its activity is a prerequisite to the induction of ATG gene transcription and Autophagy induction.
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Transcriptional regulation by Pho23 modulates the frequency of autophagosome formation.

TL;DR: The results identified Pho23 as a master transcriptional repressor for autophagy that regulates the frequency of autophagosome formation through its negative regulation of ATG9.