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David A. Tumbarello

Researcher at University of Southampton

Publications -  40
Citations -  8145

David A. Tumbarello is an academic researcher from University of Southampton. The author has contributed to research in topics: Focal adhesion & Autophagy. The author has an hindex of 21, co-authored 38 publications receiving 6574 citations. Previous affiliations of David A. Tumbarello include University of Cambridge & State University of New York Upstate Medical University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Autophagy-receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome

David A. Tumbarello, +5 more
- 30 Sep 2012 - 
TL;DR: It is proposed that myosin VI delivers endosomal membranes containing Tom1 to autophagosomes by docking to NDP52, T6BP and optineurin, thereby promoting autophagy maturation and thus driving fusion with lysosomes.
Journal ArticleDOI

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.

David A. Tumbarello, +6 more
- 09 Oct 2015 - 
TL;DR: This study identifies essential new machinery for the autophagy-dependent clearance of Salmonella typhimurium and suggests modulation of myosin VI motor activity as a potential therapeutic target in cellular immunity.
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Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition

Jeanine Pignatelli, +3 more
- 30 Apr 2012 - 
TL;DR: The focal adhesion protein Hic-5 acts through RhoC to promote TGF-β–stimulated invadopodia formation, cell migration, and invasion.