Hong Zhang

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is demonstrated that enzymes involved in the SUMO modification and demodification of proteins are components of the nuclear pore complex (NPC), and a connection between thesumO modification pathway and nucleocytoplasmic transport is suggested.

TL;DR: In this paper, digitized image data are input into a plurality of subsystems, each subsystem having one or more support vector machines, and each subsystem analyzes the data relevant to a different feature or characteristic found within the image, then the output for all subsystems is input into an overall support vector machine analyzer which combines the data to make a diagnosis, decision or other action which utilizes the knowledge obtained from the image.

TL;DR: It is found thatsumO-2/3 localize to centromeres and condensed chromosomes, whereas SUMO-1 localizes to the mitotic spindle and spindle midzone, indicating that SUMO paralogs regulate distinct mitotic processes in mammalian cells.