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Jonathan M. Backer

Researcher at Albert Einstein College of Medicine

Publications -  158
Citations -  27691

Jonathan M. Backer is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Insulin receptor & Insulin receptor substrate. The author has an hindex of 74, co-authored 156 publications receiving 25449 citations. Previous affiliations of Jonathan M. Backer include Yeshiva University & Beth Israel Deaconess Medical Center.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.

Xiao Jian Sun, +9 more
- 04 Jul 1991 - 
TL;DR: During insulin stimulation, the IRS-1 protein undergoes tyrosine phosphorylation and binds phosphatidylinositol 3-kinase, suggesting that IRS–1 acts as a multisite Mocking' protein to bind signal-transducing molecules containing Src-homology 2 and SRC-Homology-3 domains, which may link the insulin receptor kinase and enzymes regulating cellular growth and metabolism.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.

Jonathan M. Backer, +9 more
- 01 Sep 1992 - 
TL;DR: It is concluded that the binding of tyrosyl phosphorylated IRS‐1 to the SH2 domains of p85 is the critical step that activates PtdIns 3′‐kinase during insulin stimulation.
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Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex.

Yun Zhong, +8 more
- 08 Mar 2009 - 
TL;DR: It is hypothesized that by forming distinct protein complexes, Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps.