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Jean M. Mulcahy Levy

Researcher at Boston Children's Hospital

Publications -  64
Citations -  10210

Jean M. Mulcahy Levy is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 22, co-authored 56 publications receiving 7686 citations. Previous affiliations of Jean M. Mulcahy Levy include Anschutz Medical Campus & University of Colorado Denver.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Targeting autophagy in cancer

TL;DR: A way forward is suggested for the effective targeting of autophagy by understanding the context-dependent roles of autophile and by capitalizing on modern approaches to clinical trial design.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

TL;DR: This work shows that programmed necrosis is activated in response to many chemotherapeutic agents and contributes to chemotherapy-induced cell death, and proposes that RIP3-deficient cancer patients may benefit from receiving hypomethylating agents to induce RIP3 expression prior to treatment with conventional Chemotherapeutics.
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Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

TL;DR: This review considers how recent discoveries about how autophagy manipulation elicits its effects on cancer cell behavior can be leveraged to improve therapeutic responses.