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Shigeki Miyamoto

Researcher at University of California, San Diego

Publications -  73
Citations -  11490

Shigeki Miyamoto is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Mitochondrion & RHOA. The author has an hindex of 36, co-authored 59 publications receiving 9312 citations. Previous affiliations of Shigeki Miyamoto include University of California & University of California, Los Angeles.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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The δC Isoform of CaMKII Is Activated in Cardiac Hypertrophy and Induces Dilated Cardiomyopathy and Heart Failure

Tong Zhang, +7 more
- 02 May 2003 - 
TL;DR: It is demonstrated that expression of the &dgr;C isoform of CaMKII is selectively increased and its phosphorylation elevated as early as 2 days and continuously for up to 7 days after pressure overload, and this findings are the first to demonstrate that Ca MKII&d Gr;C can mediate phosphorylated of Ca2+ regulatory proteins in vivo.
Journal ArticleDOI

Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II

Shigeki Miyamoto, +2 more
- 01 Mar 2008 - 
TL;DR: Akt activation supports survival of cardiomyocytes against ischemia/reperfusion, which induces cell death through opening of the mitochondrial permeability transition pore (PT-pore) as mentioned in this paper.
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Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.

D J Roberts, +1 more
- 01 Feb 2015 - 
TL;DR: Recent advances in understanding the protective role ofHK-II are summarized, controlling cellular growth, preventing mitochondrial death pathway and enhancing autophagy, with a particular focus on the interaction between HK-II and Akt/mTOR pathway to integrate metabolic status with the control of cell survival.