Fang Hua

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: The role of β-catenin in cancer initiation, progression, dormancy, immunity and cancer stem cell maintenance is focused on, and the recent progress in the development of agents for the pharmacological modulation ofβ-Catenin activity in cancer therapy is summarized.

TL;DR: It is shown that death-effector domain-containing DNA-binding protein (DEDD) attenuates EMT and acts as an endogenous suppressor of tumor growth and metastasis, and expression levels of DEDD were conversely correlated with poor prognosis in patients with breast and colon cancer.

TL;DR: It is found that genetic or pharmacologic inhibition of TLR4 exacerbates bleomycin-induced pulmonary inflammation, fibrosis, dysfunction, and animal death through promoting formation of an immunosuppressive tissue microenvironment and attenuating autophagy-associated degradation of collagen and cell death in the fibrotic lung tissues.