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Jeffrey A. Haspel

Researcher at Washington University in St. Louis

Publications -  37
Citations -  9864

Jeffrey A. Haspel is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Autophagy & Circadian rhythm. The author has an hindex of 19, co-authored 33 publications receiving 7309 citations. Previous affiliations of Jeffrey A. Haspel include VA Boston Healthcare System & United States Department of Veterans Affairs.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Kiichi Nakahira, +14 more
- 01 Mar 2011 - 
TL;DR: This study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondria integrity and cytosolic translocation of mitochondrial DNA in response to lipopolysaccharide and ATP in macrophages.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Inflammasome-regulated cytokines are critical mediators of acute lung injury.

Tamas Dolinay, +19 more
- 01 Jun 2012 - 
TL;DR: In samples from four clinical centers, IL-18 was elevated in the plasma of patients with ARDS and served as a novel biomarker of intensive care unit morbidity and mortality and played critical roles in ARDS development.
Journal ArticleDOI

Autophagy in idiopathic pulmonary fibrosis.

Avignat Patel, +8 more
- 18 Jul 2012 - 
TL;DR: Impairment of autophagy by TGF-β1 may represent a mechanism for the promotion of fibrogenesis in IPF because it leads to the opposite effect on fibroblast expression of á-smooth muscle actin and fibronectin.