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Javier E. Irazoqui

Researcher at University of Massachusetts Medical School

Publications -  43
Citations -  10224

Javier E. Irazoqui is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: TFEB & Innate immune system. The author has an hindex of 22, co-authored 39 publications receiving 8333 citations. Previous affiliations of Javier E. Irazoqui include Duke University & Harvard University.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

Carmine Settembre, +15 more
- 01 Jun 2013 - 
TL;DR: Viral delivery of TFEB to the liver prevented weight gain and metabolic syndrome in both diet-induced and genetic mouse models of obesity, suggesting a new therapeutic strategy for disorders of lipid metabolism.
Journal ArticleDOI

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

Louis R. Lapierre, +11 more
- 08 Aug 2013 - 
TL;DR: It is demonstrated that hlh-30 is essential for the extended lifespan of Caenorhabditis elegans in six mechanistically distinct longevity models, and overexpression of HLH-30 extends lifespan, and a conserved role for HLH -30 and TFEB in autophagy, and possibly longevity is demonstrated.
Journal ArticleDOI

Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates

Javier E. Irazoqui, +2 more
- 01 Jan 2010 - 
TL;DR: Strikingly, C. elegans seems to detect, and respond to, infection without the involvement of its homologue of Toll-like receptors, in contrast to the well-established role for these proteins in innate immunity in mammals.