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Leo A. B. Joosten

Researcher at Radboud University Nijmegen

Publications -  721
Citations -  70019

Leo A. B. Joosten is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Immune system & Cytokine. The author has an hindex of 116, co-authored 650 publications receiving 55489 citations. Previous affiliations of Leo A. B. Joosten include Universidade Federal de Goiás & Iuliu Hațieganu University of Medicine and Pharmacy.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Trained immunity: A program of innate immune memory in health and disease

Mihai G. Netea, +7 more
- 22 Apr 2016 - 
TL;DR: Proof-of-principle experimental studies support the hypothesis that trained immunity is one of the main immunological processes that mediate the nonspecific protective effects against infections induced by vaccines, such as bacillus Calmette-Guérin or measles vaccination.
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mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Shih-Chin Cheng, +28 more
- 26 Sep 2014 - 
TL;DR: The identification of glycolysis as a fundamental process in trained immunity further highlights a key regulatory role for metabolism in innate host defense and defines a potential therapeutic target in both infectious and inflammatory diseases.
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Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Sadia Saeed, +31 more
- 26 Sep 2014 - 
TL;DR: The epigenetic and transcriptional programs of monocyte differentiation to macrophages that distinguish tolerant and trained macrophage phenotypes are uncovered, providing a resource to further understand and manipulate immune-mediated responses.
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Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis, +14 more
- 23 Oct 2012 - 
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.