M
Mark R. Cookson
Researcher at National Institutes of Health
Publications - 291
Citations - 43492
Mark R. Cookson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: LRRK2 & Kinase activity. The author has an hindex of 89, co-authored 278 publications receiving 36760 citations. Previous affiliations of Mark R. Cookson include Brigham and Women's Hospital & UCL Institute of Neurology.
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Guidelines for the use and interpretation of assays for monitoring autophagy
Daniel J. Klionsky,Fábio Camargo Abdalla,Hagai Abeliovich,Robert T. Abraham,Abraham Acevedo-Arozena,Khosrow Adeli,Lotta Agholme,Maria Agnello,Patrizia Agostinis,Julio A. Aguirre-Ghiso,Hyung Jun Ahn,Ouardia Ait-Mohamed,Slimane Ait-Si-Ali,Takahiko Akematsu,Shizuo Akira,Hesham M. Al-Younes,Munir A. Al-Zeer,Matthew L. Albert,Roger L. Albin,Javier Alegre-Abarrategui,Maria Francesca Aleo,Mehrdad Alirezaei,Alexandru Almasan,Maylin Almonte-Becerril,Atsuo Amano,Ravi K. Amaravadi,Shoba Amarnath,Amal O. Amer,Nathalie Andrieu-Abadie,Vellareddy Anantharam,David K. Ann,Shailendra Anoopkumar-Dukie,Hiroshi Aoki,Nadezda Apostolova,Giuseppe Arancia,John P. Aris,Katsuhiko Asanuma,Nana Asare,Hisashi Ashida,Valerie Askanas,David S. Askew,Patrick Auberger,Misuzu Baba,Steven K. Backues,Eric H. Baehrecke,Ben A. Bahr,Xue Yuan Bai,Yannick Bailly,Robert A. Baiocchi,Giulia Baldini,Walter Balduini,Andrea Ballabio,Andrea Ballabio,Bruce A. Bamber,Edward T. W. Bampton,Gábor Bánhegyi,Clinton R. Bartholomew,Diane C. Bassham,Robert C. Bast,Henri Batoko,Boon-Huat Bay,Isabelle Beau,Daniel Béchet,Thomas J. Begley,Christian Behl,Christian Behrends,Soumeya Bekri,Bryan H. Bellaire,Linda J. Bendall,Luca Benetti,Laura Berliocchi,Henri Bernardi,Francesca Bernassola,Sébastien Besteiro,Ingrid Bhatia-Kiššová,Xiaoning Bi,Martine Biard-Piechaczyk,Janice S. Blum,Lawrence H. Boise,Paolo Bonaldo,David L. Boone,Beat Bornhauser,Karina R. Bortoluci,Ioannis Bossis,Frédéric Bost,Jean-Pierre Bourquin,Patricia Boya,Michaël Boyer-Guittaut,Peter V. Bozhkov,Nathan R. Brady,Claudio Brancolini,Andreas Brech,Jay E. Brenman,Ana Brennand,Emery H. Bresnick,Patrick Brest,Dave Bridges,Molly L. Bristol,Paul S. Brookes,Eric J. Brown,John H. Brumell,Nicola Brunetti-Pierri,Ulf T. Brunk,Dennis E. Bulman,Scott J. Bultman,Geert Bultynck,Lena F. Burbulla,Wilfried Bursch,Jonathan P. Butchar,Wanda Christa Buzgariu,Sérgio Paulo Bydlowski,Ken Cadwell,Monika Cahova,Dongsheng Cai,Jiyang Cai,Qian Cai,Bruno Calabretta,Javier Calvo-Garrido,Nadine Camougrand,Michelangelo Campanella,Jenny Campos-Salinas,Eleonora Candi,Lizhi Cao,Allan Caplan,Simon R. Carding,Sandra M. Cardoso,Jennifer S. Carew,Cathleen R. Carlin,Virginie Carmignac,Leticia A.M. Carneiro,Serena Carra,Serena Carra,Rosario Caruso,Giorgio Casari,Caty Casas,Roberta Castino,Eduardo Cebollero,Francesco Cecconi,Jean Celli,Hassan Chaachouay,Han-Jung Chae,Chee Yin Chai,David C. Chan,Edmond Chan,Raymond Chuen-Chung Chang,Chi-Ming Che,Ching-Chow Chen,Guang-Chao Chen,Guo-Qiang Chen,Min Chen,Quan Chen,Quan Chen,Steve S.-L. Chen,Wen-Li Chen,Xi Chen,Xiangmei Chen,Xiequn Chen,Ye-Guang Chen,Yingyu Chen,Yongqiang Chen,Yu Jen Chen,Zhixiang Chen,Alan Cheng,Christopher H.K. Cheng,Yan Cheng,Heesun Cheong,Jae Ho Cheong,Sara Cherry,Russ Chess-Williams,Zelda H. Cheung,Eric Chevet,Hui Ling Chiang,Roberto Chiarelli,Tomoki Chiba,Lih-Shen Chin,Shih Hwa Chiou,Francis V. Chisari,Chi Hin Cho,Dong-Hyung Cho,Augustine M.K. Choi,Doo Seok Choi,Kyeong Sook Choi,Mary E. Choi,Salem Chouaib,Divaker Choubey,Vinay Choubey,Charleen T. Chu,Tsung Hsien Chuang,Sheau Huei Chueh,Taehoon Chun,Yong Joon Chwae,Mee-Len Chye,Roberto Ciarcia,Maria Rosa Ciriolo,Michael J. Clague,Robert S. B. Clark,Peter G.H. Clarke,Robert Clarke,Patrice Codogno,Hilary A. Coller,María Isabel Colombo,Sergio Comincini,Maria Condello,Fabrizio Condorelli,Mark R. Cookson,Graham H. Coombs,Isabelle Coppens,Ramón Corbalán,Pascale Cossart,Pascale Cossart,Paola Costelli,Safia Costes,Ana Coto-Montes,Eduardo Couve,Fraser P. Coxon,James M. Cregg,José L. Crespo,Marianne J. Cronjé,Ana Maria Cuervo,Joseph J. Cullen,Mark J. Czaja,Marcello D'Amelio,Arlette Darfeuille-Michaud,Lester M. Davids,Faith E. Davies,Massimo De Felici,John de Groot,Cornelis A. M. de Haan,Luisa De Martino,Angelo De Milito,Vincenzo De Tata,Jayanta Debnath,Alexei Degterev,Benjamin Dehay,Lea M.D. Delbridge,Francesca Demarchi,Yi Zhen Deng,Jörn Dengjel,Paul Dent,Donna Denton,Vojo Deretic,Shyamal D. Desai,Rodney J. Devenish,Mario Di Gioacchino,Gilbert Di Paolo,Chiara Di Pietro,Guillermo Díaz-Araya,Inés Díaz-Laviada,Maria T. Diaz-Meco,Javier Díaz-Nido,Ivan Dikic,Savithramma P. Dinesh-Kumar,Wen-Xing Ding,Clark W. Distelhorst,Abhinav Diwan,Mojgan Djavaheri-Mergny,Svetlana Dokudovskaya,Zheng Dong,Frank C. Dorsey,Victor E. Dosenko,James J. Dowling,Stephen J. Doxsey,Marlène Dreux,Mark E. Drew,Qiuhong Duan,Michel A. Duchosal,Karen Duff,Isabelle Dugail,Madeleine Durbeej,Michael Duszenko,Charles L. Edelstein,Aimee L. Edinger,Gustavo Egea,Ludwig Eichinger,N. Tony Eissa,Suhendan Ekmekcioglu,Wafik S. El-Deiry,Zvulun Elazar,Mohamed Elgendy,Lisa M. Ellerby,Kai Er Eng,Anna-Mart Engelbrecht,Simone Engelender,Jekaterina Erenpreisa,Ricardo Escalante,Audrey Esclatine,Eeva-Liisa Eskelinen,Lucile Espert,Virginia Espina,Huizhou Fan,Jia Fan,Qi-Wen Fan,Zhen Fan,Shengyun Fang,Yongqi Fang,Manolis Fanto,Alessandro Fanzani,Thomas Farkas,Jean-Claude Farré,Mathias Faure,Marcus Fechheimer,Carl G. Feng,Jian Feng,Qili Feng,Youji Feng,László Fésüs,Ralph Feuer,Maria E. Figueiredo-Pereira,Gian Maria Fimia,Diane C. Fingar,Steven Finkbeiner,Toren Finkel,Kim D. Finley,Filomena Fiorito,Edward A. Fisher,Paul B. Fisher,Marc Flajolet,Maria L. Florez-McClure,Salvatore Florio,Edward A. Fon,Francesco Fornai,Franco Fortunato,Rati Fotedar,Daniel H. Fowler,Howard S. Fox,Rodrigo Franco,Lisa B. Frankel,Marc Fransen,José M. Fuentes,Juan Fueyo,Jun Fujii,Kozo Fujisaki,Eriko Fujita,Mitsunori Fukuda,Ruth Furukawa,Matthias Gaestel,Philippe Gailly,Małgorzata Gajewska,Brigitte Galliot,Vincent Galy,Subramaniam Ganesh,Barry Ganetzky,Ian G. Ganley,Fen-Biao Gao,George F. Gao,Jinming Gao,Lorena García,Guillermo Garcia-Manero,Mikel Garcia-Marcos,Marjan Garmyn,Andrei L. Gartel,Evelina Gatti,Mathias Gautel,Thomas R. Gawriluk,Matthew E. Gegg,Jiefei Geng,Marc Germain,Jason E. Gestwicki,David A. Gewirtz,Saeid Ghavami,Pradipta Ghosh,Anna Maria Giammarioli,Alexandra Giatromanolaki,Spencer B. Gibson,Robert Gilkerson,Michael L. Ginger,Henry N. Ginsberg,Jakub Golab,Michael S. Goligorsky,Pierre Golstein,Candelaria Gomez-Manzano,Ebru Goncu,Céline Gongora,Claudio Gonzalez,Ramon Gonzalez,Cristina González-Estévez,Rosa A. González-Polo,Elena Gonzalez-Rey,Nikolai V. Gorbunov,Sharon M. Gorski,Sandro Goruppi,Roberta A. Gottlieb,Devrim Gozuacik,Giovanna Elvira Granato,Gary Grant,Kim N. Green,Aleš Gregorc,Frédéric Gros,Charles Grose,Thomas W. Grunt,Philippe Gual,Jun-Lin Guan,Kun-Liang Guan,Sylvie Guichard,Anna S. Gukovskaya,Ilya Gukovsky,Jan Gunst,Åsa B. Gustafsson,Andrew J. Halayko,Amber N. Hale,Sandra K. Halonen,Maho Hamasaki,Feng Han,Ting Han,Michael K. Hancock,Malene Hansen,Hisashi Harada,Masaru Harada,Stefan E. Hardt,J. Wade Harper,Adrian L. Harris,James Harris,Steven D. Harris,Makoto Hashimoto,Jeffrey A. Haspel,Jeffrey A. Haspel,Shin Ichiro Hayashi,Lori A. Hazelhurst,Congcong He,You-Wen He,Marie-Josée Hébert,Kim A. Heidenreich,Miep H. Helfrich,Gudmundur Vignir Helgason,Elizabeth P. Henske,Brian Herman,Paul K. Herman,Claudio Hetz,Sabine Hilfiker,Joseph A. Hill,Lynne J. Hocking,Paul Hofman,Thomas G. Hofmann,Jörg Höhfeld,Tessa L. Holyoake,Ming Huang Hong,David A. Hood,Gökhan S. Hotamisligil,Ewout J. Houwerzijl,Maria Høyer-Hansen,Bingren Hu,Chien-An Andy Hu,Hong-Ming Hu,Ya Hua,Canhua Huang,Ju Huang,Shengbing Huang,Wei-Pang Huang,Tobias B. Huber,Won-Ki Huh,Tai-Ho Hung,Ted R. Hupp,Gang Min Hur,James B. Hurley,Sabah N. A. Hussain,Patrick J. Hussey,Jung Jin Hwang,Seungmin Hwang,Atsuhiro Ichihara,Shirin Ilkhanizadeh,Ken Inoki,Takeshi Into,Valentina Iovane,Juan L. Iovanna,Nancy Y. Ip,Yoshitaka Isaka,Hiroyuki Ishida,Ciro Isidoro,Ken-ichi Isobe,Akiko Iwasaki,Marta Izquierdo,Yotaro Izumi,Panu Jaakkola,Marja Jäättelä,George R. Jackson,William T. Jackson,Bassam Janji,Marina Jendrach,Ju Hong Jeon,Eui-Bae Jeung,Hong Jiang,Hongchi Jiang,Jean X. Jiang,Ming Jiang,Qing Jiang,Xuejun Jiang,Alberto Jiménez,Meiyan Jin,Shengkan Jin,Cheol O. Joe,Terje Johansen,Daniel Johnson,Gail V.W. Johnson,Nicola L. Jones,Bertrand Joseph,Suresh K. Joseph,Annie M. Joubert,Gábor Juhász,Lucienne Juillerat-Jeanneret,Chang Hwa Jung,Yong-Keun Jung,Kai Kaarniranta,Allen Kaasik,Tomohiro Kabuta,Motoni Kadowaki,Katarina Kågedal,Yoshiaki Kamada,Vitaliy O. Kaminskyy,Harm H. Kampinga,Hiromitsu Kanamori,Chanhee Kang,Khong Bee Kang,Kwang Il Kang,Rui Kang,Yoon-A Kang,Tomotake Kanki,Thirumala-Devi Kanneganti,Haruo Kanno,Anumantha G. Kanthasamy,Arthi Kanthasamy,Vassiliki Karantza,Gur P. Kaushal,Susmita Kaushik,Yoshinori Kawazoe,Po-Yuan Ke,Po-Yuan Ke,John H. Kehrl,Ameeta Kelekar,Claus Kerkhoff,David Kessel,Hany Khalil,Jan A.K.W. Kiel,Amy A. Kiger,Akio Kihara,Deok Ryong Kim,Do Hyung Kim,Dong Hou Kim,Eun Kyoung Kim,Hyung Ryong Kim,Jae-Sung Kim,Jeong Hun Kim,Jin Cheon Kim,John Kim,Peter K. Kim,Seong Who Kim,Yong-Sun Kim,Yonghyun Kim,Adi Kimchi,Alec C. Kimmelman,Jason S. King,Timothy J. Kinsella,Vladimir Kirkin,Lorrie A. Kirshenbaum,Katsuhiko Kitamoto,Kaio Kitazato,Ludger Klein,Walter T. Klimecki,Jochen Klucken,Erwin Knecht,Ben C.B. Ko,Jan C. Koch,Hiroshi Koga,Jae-Young Koh,Young Ho Koh,Masato Koike,Masaaki Komatsu,Eiki Kominami,Hee Jeong Kong,Weijia Kong,Viktor I. Korolchuk,Yaichiro Kotake,Michael I. Koukourakis,Juan Kourí Flores,Attila L. Kovács,Claudine Kraft,Dimitri Krainc,Helmut Krämer,Carole Kretz-Remy,Carole Kretz-Remy,Anna M. Krichevsky,Guido Kroemer,Rejko Krüger,Oleg Krut,Nicholas T. Ktistakis,Chia Yi Kuan,Roza Kucharczyk,Ashok Kumar,Raj Kumar,Sharad Kumar,Mondira Kundu,Hsing Jien Kung,Tino Kurz,Ho Jeong Kwon,Albert R. La Spada,Albert R. La Spada,Frank Lafont,Trond Lamark,Jacques Landry,Jon D. Lane,Pierre Lapaquette,Jocelyn Laporte,Lajos László,Sergio Lavandero,Sergio Lavandero,Josée N. Lavoie,Robert Layfield,Pedro A. Lazo,Weidong Le,Laurent Le Cam,Daniel J. Ledbetter,Alvin J.X. Lee,Byung Wan Lee,Gyun Min Lee,Jongdae Lee,Ju-Hyun Lee,Michael Lee,Myung-Shik Lee,Sug Hyung Lee,Christiaan Leeuwenburgh,Patrick Legembre,Renaud Legouis,Michael Lehmann,Huan Yao Lei,Qun-Ying Lei,David A. Leib,José Leiro,John J. Lemasters,Antoinette Lemoine,Maciej S. Lesniak,Dina Lev,Victor V. Levenson,Beth Levine,Efrat Levy,Faqiang Li,Jun Lin Li,Lian Li,Sheng Li,Weijie Li,Xue-Jun Li,Yan Bo Li,Yi Ping Li,Chengyu Liang,Qiangrong Liang,Yung Feng Liao,Pawel P. Liberski,Andrew P. Lieberman,Hyunjung Jade Lim,Kah-Leong Lim,Kyu Lim,Chiou Feng Lin,Fu-Cheng Lin,Jian Lin,Jiandie D. Lin,Kui Lin,Wan-Wan Lin,Weei-Chin Lin,Yi-Ling Lin,Rafael Linden,Paul Lingor,Jennifer Lippincott-Schwartz,Michael P. Lisanti,Michael P. Lisanti,Paloma B. Liton,Bo Liu,Chun-Feng Liu,Kaiyu Liu,Leyuan Liu,Qiong A. Liu,Wei Liu,Young Chau Liu,Yule Liu,Richard A. Lockshin,Chun-Nam Lok,Sagar Lonial,Benjamin Loos,Gabriel Lopez-Berestein,Carlos López-Otín,Laura Lossi,Michael T. Lotze,Péter Löw,Binfeng Lu,Bingwei Lu,Bo Lu,Zhen Lu,Frederic Luciano,Nicholas W. Lukacs,Anders H. Lund,Melinda A. Lynch-Day,Yong Ma,Fernando Macian,Jeffrey P. MacKeigan,Kay F. Macleod,Frank Madeo,Luigi Maiuri,Maria Chiara Maiuri,Davide Malagoli,May Christine V. Malicdan,Walter Malorni,Na Man,Eva Maria Mandelkow,Stéphen Manon,Irena Manov,Kai Mao,Xiang Mao,Zixu Mao,Philippe Marambaud,Daniela Marazziti,Yves L. Marcel,Katie Marchbank,Piero Marchetti,Stefan J. Marciniak,Mateus Marcondes,Mohsen Mardi,Gabriella Marfe,Guillermo Mariño,Maria Markaki,Maria Markaki,Mark R. Marten,Seamus J. Martin,Camille Martinand-Mari,Wim Martinet,Marta Martinez-Vicente,Matilde Masini,Paola Matarrese,Saburo Matsuo,Raffaele Matteoni,Andreas Mayer,Nathalie M. Mazure,David J. McConkey,Melanie J. McConnell,Catherine McDermott,Christine McDonald,Gerald M. McInerney,Sharon L. McKenna,BethAnn McLaughlin,Pamela J. McLean,Christopher R. McMaster,G. Angus McQuibban,Alfred J. Meijer,Miriam H. Meisler,Alicia Meléndez,Thomas J. Melia,Gerry Melino,Gerry Melino,Maria Angeles Mena,Javier A. Menendez,Rubem F. S. Menna-Barreto,Manoj B. Menon,Fiona M. Menzies,Carol A. Mercer,Adalberto Merighi,Diane E. Merry,Stefania Meschini,Christian Meyer,Thomas F. Meyer,Chao-Yu Miao,Jun-Ying Miao,Paul A.M. Michels,Carine Michiels,Dalibor Mijaljica,Ana Milojkovic,Saverio Minucci,Clelia Miracco,Cindy K. Miranti,Ioannis Mitroulis,Keisuke Miyazawa,Noboru Mizushima,Baharia Mograbi,Simin Mohseni,Xavier Molero,Bertrand Mollereau,Faustino Mollinedo,Takashi Momoi,Iryna Monastyrska,Martha M. Monick,Mervyn J. Monteiro,Michael Moore,Rodrigo Mora,Kevin Moreau,Paula I. Moreira,Yuji Moriyasu,Jorge Moscat,Serge Mostowy,Jeremy C. Mottram,Tomasz Motyl,Charbel Moussa,Sylke Müller,Sylviane Muller,Karl Münger,Christian Münz,Leon Murphy,Maureen E. Murphy,Antonio Musarò,Indira U. Mysorekar,Eiichiro Nagata,Kazuhiro Nagata,Aimable Nahimana,Usha Nair,Toshiyuki Nakagawa,Kiichi Nakahira,Hiroyasu Nakano,Hitoshi Nakatogawa,Meera Nanjundan,Naweed I. Naqvi,Derek P. Narendra,Masashi Narita,Miguel Navarro,Steffan T. Nawrocki,Taras Y. Nazarko,Andriy Nemchenko,Mihai G. Netea,Thomas P. Neufeld,Paul A. Ney,Ioannis P. Nezis,Huu Phuc Nguyen,Daotai Nie,Ichizo Nishino,Corey Nislow,Ralph A. Nixon,Takeshi Noda,Angelika A. Noegel,Anna Nogalska,Satoru Noguchi,Lucia Notterpek,Ivana Novak,Tomoyoshi Nozaki,Tomoyoshi Nozaki,Nobuyuki Nukina,Thorsten Nürnberger,Beat Nyfeler,Keisuke Obara,Terry D. Oberley,Salvatore Oddo,Michinaga Ogawa,Toya Ohashi,Koji Okamoto,Nancy L. Oleinick,F. Javier Oliver,Laura J. Olsen,Stefan Olsson,Onya Opota,Timothy F. Osborne,Gary K. Ostrander,Kinya Otsu,Jing Hsiung James Ou,Mireille Ouimet,Michael Overholtzer,Bulent Ozpolat,Paolo Paganetti,Ugo Pagnini,Nicolas Pallet,Glen E. Palmer,Camilla Palumbo,Tianhong Pan,Theocharis Panaretakis,Udai Bhan Pandey,Zuzana Papackova,Issidora S. Papassideri,Irmgard Paris,Irmgard Paris,Junsoo Park,Ohkmae K. Park,Jan B. Parys,Katherine R. Parzych,Susann Patschan,W. Cam Patterson,Sophie Pattingre,John M. Pawelek,Jianxin Peng,David H. Perlmutter,Ida Perrotta,George Perry,Shazib Pervaiz,Matthias Peter,Godefridus J. Peters,Morten Petersen,Goran Petrovski,James M. Phang,Mauro Piacentini,Philippe Pierre,Valérie Pierrefite-Carle,Gérard Pierron,Ronit Pinkas-Kramarski,Antonio Piras,Natik Piri,Leonidas C. Platanias,Stefanie Pöggeler,Marc Poirot,Angelo Poletti,Christian Poüs,Mercedes Pozuelo-Rubio,Mette Prætorius-Ibba,Anil Prasad,Mark Prescott,Muriel Priault,Nathalie Produit-Zengaffinen,Ann Progulske-Fox,Tassula Proikas-Cezanne,Serge Przedborski,Karin Przyklenk,Rosa Puertollano,Julien Puyal,Shu-Bing Qian,Liang Qin,Zheng-Hong Qin,Susan E. Quaggin,Nina Raben,Hannah Rabinowich,Simon W. Rabkin,Irfan Rahman,Abdelhaq Rami,Georg Ramm,Glenn Randall,Felix Randow,V. Ashutosh Rao,Jeffrey C. Rathmell,Brinda Ravikumar,Swapan K. Ray,Bruce H. Reed,John C. Reed,Fulvio Reggiori,Anne Régnier-Vigouroux,Anne Régnier-Vigouroux,Andreas S. Reichert,John J. Reiners,Russel J. Reiter,Jun Ren,José L. Revuelta,Christopher J. Rhodes,Konstantinos Ritis,Elizete Rizzo,Jeffrey Robbins,Michel Roberge,Hernan Roca,Maria Carmela Roccheri,Stéphane Rocchi,H. Peter Rodemann,Santiago Rodríguez de Córdoba,Bärbel Rohrer,Igor B. Roninson,Kirill V. Rosen,Magdalena Rost-Roszkowska,Mustapha Rouis,Kasper M.A. Rouschop,Francesca Rovetta,Brian P. Rubin,David C. Rubinsztein,Klaus Ruckdeschel,Edmund B. Rucker,Assaf Rudich,Emil Rudolf,Nelson Ruiz-Opazo,Rossella Russo,Tor Erik Rusten,Kevin M. Ryan,Stefan W. Ryter,David M. Sabatini,Junichi Sadoshima,Tapas Saha,Tatsuya Saitoh,Hiroshi Sakagami,Yasuyoshi Sakai,Ghasem Hosseini Salekdeh,Paolo Salomoni,Paul M. Salvaterra,Guy S. Salvesen,Rosa Salvioli,Anthony Sanchez,José Antonio Sánchez-Alcázar,Ricardo Sánchez-Prieto,Marco Sandri,Uma Sankar,Poonam Sansanwal,Laura Santambrogio,Shweta Saran,Sovan Sarkar,Minnie M. Sarwal,Chihiro Sasakawa,Ausra Sasnauskiene,Miklós Sass,Ken Sato,Miyuki Sato,Anthony H.V. Schapira,Michael Scharl,Hermann M. Schätzl,Wiep Scheper,Stefano Schiaffino,Claudio Schneider,Marion Schneider,Regine Schneider-Stock,Patricia V. Schoenlein,Daniel F. Schorderet,Christoph Schüller,Gary K. Schwartz,Luca Scorrano,Linda Sealy,Per Ottar Seglen,Juan Segura-Aguilar,Iban Seiliez,Oleksandr Seleverstov,Christian Sell,Jong Bok Seo,Duska Separovic,Vijayasaradhi Setaluri,Takao Setoguchi,Carmine Settembre,John J. Shacka,Mala Shanmugam,Irving M. Shapiro,Eitan Shaulian,Reuben J. Shaw,James H. Shelhamer,Han-Ming Shen,Wei-Chiang Shen,Zu-Hang Sheng,Yang Shi,Kenichi Shibuya,Yoshihiro Shidoji,Jeng-Jer Shieh,Chwen Ming Shih,Yohta Shimada,Shigeomi Shimizu,Takahiro Shintani,Orian S. Shirihai,Gordon C. Shore,Andriy A. Sibirny,Andriy A. Sibirny,Stan B. Sidhu,Beata Sikorska,Elaine C.M. Silva-Zacarin,Alison Simmons,Anna Katharina Simon,Hans-Uwe Simon,Cristiano Simone,Anne Simonsen,David A. Sinclair,Rajat Singh,Debasish Sinha,Frank A. Sinicrope,Agnieszka Sirko,Parco M. Siu,Efthimios Sivridis,Vojtech Skop,Vladimir P. Skulachev,Ruth S. Slack,Soraya S. Smaili,Duncan R. Smith,Maria S. Soengas,Thierry Soldati,Xueqin Song,Anil K. Sood,Tuck Wah Soong,Federica Sotgia,Stephen A. Spector,Stephen A. Spector,Claudia Spies,Wolfdieter Springer,Srinivasa M. Srinivasula,Leonidas Stefanis,Joan S. Steffan,Ruediger Stendel,Harald Stenmark,Anastasis Stephanou,Stephan T. Stern,Cinthya Sternberg,Björn Stork,Peter Strålfors,Carlos S. Subauste,Xinbing Sui,David Sulzer,Jiaren Sun,Shi-Yong Sun,Zhi Jun Sun,Joseph J.Y. Sung,Kuninori Suzuki,Toshihiko Suzuki,Michele S. Swanson,Charles Swanton,Sean T. Sweeney,Lai King Sy,Gyorgy Szabadkai,Ira Tabas,Heinrich Taegtmeyer,Marco Tafani,Krisztina Takács-Vellai,Yoshitaka Takano,Kaoru Takegawa,Genzou Takemura,Fumihiko Takeshita,Nicholas J. Talbot,Kevin S. W. Tan,Keiji Tanaka,Kozo Tanaka,Daolin Tang,Dingzhong Tang,Isei Tanida,Bakhos A. Tannous,Nektarios Tavernarakis,Graham S. Taylor,Gregory A. Taylor,J. Paul Taylor,Ance S. Terada,Alexei Terman,Gianluca Tettamanti,Karin Thevissen,Craig B. Thompson,Andrew Thorburn,Michael Thumm,Feng Feng Tian,Yuan Tian,Glauco P. Tocchini-Valentini,Aviva M. Tolkovsky,Yasuhiko Tomino,Lars Tönges,Sharon A. Tooze,Cathy Tournier,John Tower,Roberto Towns,Vladimir Trajkovic,Leonardo H. Travassos,Ting Fen Tsai,Mario P. Tschan,Takeshi Tsubata,Allan Tsung,Boris Turk,Lorianne S. Turner,Suresh C. Tyagi,Yasuo Uchiyama,Takashi Ueno,Midori Umekawa,Rika Umemiya-Shirafuji,Vivek K. Unni,Maria I. Vaccaro,Enza Maria Valente,Enza Maria Valente,Greet Van den Berghe,Ida J. van der Klei,Wouter G. van Doorn,Linda F. van Dyk,Marjolein van Egmond,Leo A. van Grunsven,Peter Vandenabeele,Wim Vandenberghe,Ilse Vanhorebeek,Eva C. Vaquero,Guillermo Velasco,Tibor Vellai,Jose Miguel Vicencio,Richard D. Vierstra,Miquel Vila,Cécile Vindis,Cécile Vindis,Giampietro Viola,Maria Teresa Viscomi,Olga V. Voitsekhovskaja,Clarissa von Haefen,Marcela Votruba,Keiji Wada,Richard Wade-Martins,Cheryl L. Walker,Craig M. Walsh,Jochen Walter,Xiang Bo Wan,Aimin Wang,Chenguang Wang,Dawei Wang,Fan Wang,Fen Wang,Guanghui Wang,Haichao Wang,Hong Gang Wang,Horng-Dar Wang,Jin Wang,Ke Wang,Mei Wang,Richard C. Wang,Xinglong Wang,Xuejun Wang,Ying Jan Wang,Yipeng Wang,Zhen Wang,Zhigang Charles Wang,Zhi-Nong Wang,Derick G. Wansink,Diane M. Ward,Hirotaka Watada,Sarah Waters,Paul Webster,Lixin Wei,Conrad C. Weihl,William A. Weiss,Scott M. Welford,Longping Wen,Caroline A. Whitehouse,J. Lindsay Whitton,Alexander J. Whitworth,Thomas Wileman,John W. Wiley,Simon Wilkinson,Dieter Willbold,Roger L. Williams,Peter R. Williamson,Bradly G. Wouters,Chenghan Wu,Dao Cheng Wu,William K.K. Wu,Andreas Wyttenbach,Ramnik J. Xavier,Zhijun Xi,Pu Xia,Gengfu Xiao,Zhiping Xie,Zhonglin Xie,Da Zhi Xu,Jianzhen Xu,Liang Xu,Xiaolei Xu,Ai Yamamoto,Akitsugu Yamamoto,Shunhei Yamashina,Michiaki Yamashita,Xianghua Yan,Mitsuhiro Yanagida,Dun-Sheng Yang,Elizabeth Yang,Jin Ming Yang,Shi Yu Yang,Wannian Yang,Wei Yuan Yang,Zhifen Yang,Meng-Chao Yao,Tso-Pang Yao,Behzad Yeganeh,Wei Lien Yen,Jia Jing Yin,Xiao Ming Yin,Ook Joon Yoo,Gyesoon Yoon,Seung Yong Yoon,Tomohiro Yorimitsu,Yuko Yoshikawa,Tamotsu Yoshimori,Kohki Yoshimoto,Ho Jin You,Richard J. Youle,Anas Younes,Li Yu,Long Yu,Seong-Woon Yu,Wai Haung Yu,Zhi-Min Yuan,Zhenyu Yue,Cheol-Heui Yun,Michisuke Yuzaki,Olga Zabirnyk,Elaine Silva-Zacarin,E. David Zacks,Ldad Zacksenhaus,Nadia Zaffaroni,Zahra Zakeri,Herbert J. Zeh,Scott Zeitlin,Hong Zhang,Hui Ling Zhang,Jianhua Zhang,Jing Pu Zhang,Lin Zhang,Long Zhang,Ming Yong Zhang,Xudong Zhang,Mantong Zhao,Yi Fang Zhao,Ying Zhao,Zhizhuang J. Zhao,Xiaoxiang Zheng,Boris Zhivotovsky,Qing Zhong,Cong Zhao Zhou,Changlian Zhu,Wei-Guo Zhu,Xiao Feng Zhu,Xiongwei Zhu,Yuangang Zhu,Teresa Zoladek,Wei-Xing Zong,Antonio Zorzano,Jürgen Zschocke,Brian S. Zuckerbraun +1287 more
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI
α-Synuclein Locus Triplication Causes Parkinson's Disease
Andrew B. Singleton,Matthew J. Farrer,Joshua C. Johnson,Amanda Singleton,Stephen Hague,Jennifer M. Kachergus,Mary M. Hulihan,Terhi Peuralinna,Amalia Dutra,Robert L. Nussbaum,Sarah Lincoln,Anthony Crawley,Melissa Hanson,Demetrius M. Maraganore,Charles H. Adler,Mark R. Cookson,Manfred D. Muenter,Melisa J. Baptista,David Miller,J. Blancato,John Hardy,Katrina Gwinn-Hardy +21 more
TL;DR: In this article, the α-synuclein was identified as the major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and of glial cell cytoplasmic inclusions.
Journal ArticleDOI
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
Derek P. Narendra,Seok Min Jin,Atsushi Tanaka,Der-Fen Suen,Clement A. Gautier,Jie Shen,Mark R. Cookson,Richard J. Youle +7 more
TL;DR: The authors suggest that PINK1 and Parkin form a pathway that senses damaged mitochondria and selectively targets them for degradation.
Journal ArticleDOI
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Javier Simón-Sánchez,Claudia Schulte,Jose Bras,Jose Bras,Manu Sharma,J. Raphael Gibbs,J. Raphael Gibbs,Daniela Berg,Coro Paisán-Ruiz,Peter Lichtner,Sonja W. Scholz,Sonja W. Scholz,Dena G. Hernandez,Dena G. Hernandez,Rejko Krüger,Monica Federoff,Christine Klein,Alison Goate,Joel S. Perlmutter,Michael Bonin,Mike A. Nalls,Thomas Illig,Christian Gieger,Henry Houlden,Michael Steffens,Michael S. Okun,Brad A. Racette,Mark R. Cookson,Kelly D. Foote,Hubert H. Fernandez,Bryan J. Traynor,Stefan Schreiber,Sampath Arepalli,Ryan R. Zonozi,Katrina Gwinn,Marcel P. van der Brug,Marcel P. van der Brug,Grisel Lopez,Stephen J. Chanock,Arthur Schatzkin,Yikyung Park,Albert R. Hollenbeck,Jianjun Gao,Xuemei Huang,Nicholas W. Wood,Delia Lorenz,Günther Deuschl,Honglei Chen,Olaf Riess,John Hardy,Andrew B. Singleton,Thomas Gasser +51 more
TL;DR: It is demonstrated that an unequivocal role for common genetic variants in the etiology of typical PD and population-specific genetic heterogeneity in this disease is suggested, and supporting evidence that common variation around LRRK2 modulates risk for PD is provided.
Journal ArticleDOI
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Mike A. Nalls,Cornelis Blauwendraat,Costanza L. Vallerga,Karl Heilbron,Sara Bandres-Ciga,Diana Chang,Manuela Tan,Demis A. Kia,Alastair J. Noyce,Alastair J. Noyce,Angli Xue,Jose Bras,Jose Bras,Emily Young,Rainer von Coelln,Javier Simón-Sánchez,Javier Simón-Sánchez,Claudia Schulte,Claudia Schulte,Manu Sharma,Lynne Krohn,Lynne Krohn,Lasse Pihlstrøm,Ari Siitonen,Ari Siitonen,Hirotaka Iwaki,Hirotaka Iwaki,Leonard H,Faraz Faghri,Faraz Faghri,J. Raphael Gibbs,Dena G. Hernandez,Sonja W. Scholz,Sonja W. Scholz,Juan A. Botía,Juan A. Botía,Maria Martinez,Maria Martinez,Jean-Christophe Corvol,Suzanne Lesage,Joseph Jankovic,Lisa M. Shulman,Margaret Sutherland,Pentti J. Tienari,Kari Majamaa,Kari Majamaa,Mathias Toft,Mathias Toft,Ole A. Andreassen,Ole A. Andreassen,Tushar Bangale,Alexis Brice,Jian Yang,Ziv Gan-Or,Ziv Gan-Or,Thomas Gasser,Thomas Gasser,Peter Heutink,Peter Heutink,Joshua M. Shulman,Nicholas W. Wood,David A. Hinds,John Hardy,Huw R. Morris,Jacob Gratten,Peter M. Visscher,Robert R. Graham,Andrew B. Singleton,Astrid Adarmes-Gómez,Miquel Aguilar,Akbota Aitkulova,Vadim Akhmetzhanov,Roy N. Alcalay,Ignacio Alvarez,Victoria Alvarez,Francisco J. Barrero,Jesús Alberto Bergareche Yarza,Inmaculada Bernal-Bernal,Kimberley Billingsley,Marta Blazquez,Marta Bonilla-Toribio,María Teresa Boungiorno,Kathrin Brockmann,Vivien J. Bubb,Dolores Buiza-Rueda,Ana Cámara,Fátima Carrillo,Mario Carrión-Claro,Debora Cerdan,Viorica Chelban,Jordi Clarimón,Carl E Clarke,Yaroslau Compta,Mark R. Cookson,David Craig,Fabrice Danjou,Monica Diez-Fairen,Oriol Dols-Icardo,Jacinto Duarte,Raquel Duran,Francisco Escamilla-Sevilla,Valentina Escott-Price,Mario Ezquerra,Cici Feliz,Manel Fernández,Rubén Fernández-Santiago,Steven Finkbeiner,Thomas Foltynie,Ciara Garcia,Pedro J. Garcia-Ruiz,Maria Jose Gomez Heredia,Pilar Gómez-Garre,Manuel Menéndez González,Isabel González-Aramburu,Sebastian Guelfi,Rita Guerreiro,John Hardy,Sharon Hassin-Baer,Janet Hoenicka,Peter Holmans,Henry Houlden,Jon Infante,Silvia Jesús,Adriano Jimenez-Escrig,Gulnaz Kaishybayeva,Rauan Kaiyrzhanov,Altynay Karimova,Kerri J. Kinghorn,Sulev Kõks,Jaime Kulisevsky,Miguel A. Labrador-Espinosa,Hampton L. Leonard,Patrick A. Lewis,Jose Lopez-Sendon,Ruth C. Lovering,Steven J. Lubbe,Codrin Lungu,Daniel Macias,Claudia Manzoni,Juan Marín,Johan Marinus,María José Martí,Irene Martínez Torres,Juan Carlos Martínez-Castrillo,Marina Mata,Niccolo E. Mencacci,Carlota Méndez-del-Barrio,Ben Middlehurst,Adolfo Mínguez,Pablo Mir,Kin Y. Mok,Esteban Muñoz,Derek P. Narendra,Oluwadamilola O. Ojo,Njideka U Okubadejo,Ana Gorostidi Pagola,Pau Pastor,Francisco Perez Errazquin,Teresa Periñán-Tocino,Helene Plun-Favreau,John P. Quinn,Lea R'Bibo,Xylena Reed,Elisabet Mondragon Rezola,Mie Rizig,Patrizia Rizzu,Laurie Robak,Antonio Sanchez Rodriguez,Guy A. Rouleau,Javier Ruiz-Martínez,Clara Ruz,Mina Ryten,Dinara Sadykova,Sebastian R Schreglmann,Chingiz Shashkin,María Sierra,Esther Suarez-Sanmartin,Pille Taba,Cesar Tabernero,Manuela X Tan,Juan Pablo Tartari,Cristina Tejera-Parrado,Eduard Tolosa,Daniah Trabzuni,Francesc Valldeoriola,Jacobus J. van Hilten,Kendall Van Keuren-Jensen,Laura Vargas-González,Lydia Vela,Francisco Vives,Nigel Williams,Nazira Zharkinbekova,Zharkyn Zharmukhanov,Elena Zholdybayeva,Alexander Zimprich,Pauli Ylikotila,Stephen G. Reich,Joseph M. Savitt,Michelle Agee,Babak Alipanahi,Adam Auton,Robert K. Bell,Katarzyna Bryc,Sarah L. Elson,Pierre Fontanillas,Nicholas A. Furlotte,Karen E. Huber,Barry W. Hicks,Ethan M. Jewett,Yunxuan Jiang,Aaron Kleinman,Keng-Han Lin,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Kimberly F. McManus,Joanna L. Mountain,Elizabeth S. Noblin,Carrie A.M. Northover,Steven J. Pitts,G. David Poznik,J. Fah Sathirapongsasuti,Janie F. Shelton,Suyash Shringarpure,Chao Tian,Joyce Y. Tung,Vladimir Vacic,Xin Wang,Catherine H. Wilson,Tim J. Anderson,Steven R. Bentley,John C. Dalrymple-Alford,Javed Fowdar,Glenda M. Halliday,Anjali K. Henders,Ian B. Hickie,Irfahan Kassam,Martin A. Kennedy,John B.J. Kwok,Simon J.G. Lewis,George D. Mellick,Grant W. Montgomery,John F. Pearson,Toni L. Pitcher,Julia Sidorenko,Peter A. Silburn,Leanne Wallace,Naomi R. Wray,Futao Zhang +248 more
TL;DR: These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified.