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Ruben K. Dagda

Researcher at University of Nevada, Reno

Publications -  67
Citations -  10797

Ruben K. Dagda is an academic researcher from University of Nevada, Reno. The author has contributed to research in topics: Mitochondrion & PINK1. The author has an hindex of 33, co-authored 61 publications receiving 8895 citations. Previous affiliations of Ruben K. Dagda include Roy J. and Lucille A. Carver College of Medicine & University of Nevada, Reno School of Medicine.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

Ruben K. Dagda, +6 more
- 15 May 2009 - 
TL;DR: It is found that loss of PINK1 function elicits oxidative stress and mitochondrial turnover coordinated by the autophagic and fission/fusion machineries, and Pink1 and Parkin may cooperate through different mechanisms to maintain mitochondrial homeostasis.
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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

Charleen T. Chu, +25 more
- 01 Oct 2013 - 
TL;DR: Red redistribution of cardiolipin serves as an ‘eat-me’ signal for the elimination of damaged mitochondria from neuronal cells as well as the engulfment of mitochondria by the autophagic system.
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Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease.

Ruben K. Dagda, +3 more
- 27 Jun 2008 - 
TL;DR: It is shown that 6-hydroxydopamine elicits activity-related localization of ERK1/2 in mitochondria of SH-SY5Y cells, and these events coincide with induction of autophagy and precede mitochondrial degradation, indicating that mitochondrial localization ofERK2 activity is sufficient to recapitulate the effects of 6-OHDA on mitophagyand autophagic cell death.