Young J. Oh

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: Data suggest that minocycline treatment modulated expression of cytokines, attenuated cell death and the size of lesions, and improved functional recovery in the injured rat, suggesting that this approach may provide a therapeutic intervention enabling us to reduce cellDeath and improve functional recovery after SCI.

TL;DR: The possibility that MPTP and 6‐hydroxydopamine act on distinct cell death pathways in a murine dopaminergic neuronal cell line is examined, finding that cells treated with 6‐OHDA accompanied ultrastructural changes typical of apoptosis, whereas MPP+ treatment induced necrotic manifestations.

TL;DR: Proteotoxic stress imposed by the proteasome inhibition or expression of polyglutamine expanded huntingtin induces p62 phosphorylation at its ubiquitin-association (UBA) domain that regulates its binding to ubiquitinated proteins, suggesting a potential novel drug target for the treatment of proteinopathies including Huntington's disease.