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Simon Sedej

Researcher at Medical University of Graz

Publications -  73
Citations -  9133

Simon Sedej is an academic researcher from Medical University of Graz. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 23, co-authored 57 publications receiving 7114 citations. Previous affiliations of Simon Sedej include University of Ljubljana & University of Graz.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Cardioprotection and lifespan extension by the natural polyamine spermidine

Tobias Eisenberg, +69 more
- 01 Dec 2016 - 
TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.
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Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.

Tobias Eisenberg, +41 more
- 04 Mar 2014 - 
TL;DR: It is shown that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autophagy during aging in yeast, and brain-specific knockdown of Drosophila AcCoA synthetase was sufficient to enhance autophagic protein clearance and prolong lifespan.
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Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue

Renate Schreiber, +12 more
- 07 Nov 2017 - 
TL;DR: It is concluded that functional NST requires adequate substrate supply and cardiac function, but does not depend on ATGL-mediated lipolysis in BAT, suggesting that circulating energy substrates are sufficient to fuel NST.