Hengyi Xiao

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: The results demonstrate convergence between AMPK and Nrf2 pathways and this intersection is essential for anti-inflammatory effect of BBR in LPS-stimulated macrophages and endotoxin-shocked mice.

TL;DR: Recent advances in TAM‐targeted strategies for tumour therapy are summarized and four strategies are grouped into four categories: inhibiting macrophage recruitment; suppressing TAM survival; enhancing M1‐like tumoricidal activity of TAMs; blocking M2‐ like tumour‐promoting activity of Tams.

TL;DR: It is found that mitochondrial dysfunction plays an initiating role, while lysosomal dysfunction is more directly responsible for autophagy impairment and senescence, and the effect of rapamycin on autophagic flux is linked to its role in functional revitalization of both mitochondrial and lysOSomal functions.