Jean-Paul Decuypere

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is revealed that PERK (RNA-dependent protein kinase (PKR)-like ER kinase), a key ER stress sensor of the unfolded protein response, is uniquely enriched at the mitochondria-associated ER membranes (MAMs), suggesting that loss of PERK may cause defects in cell death sensitivity in pathological conditions linked to ROS-mediated ER stress.

TL;DR: A critical overview of the literature is provided and a model explaining how changes in intracellular Ca(2+) signaling can lead to opposite outcomes, depending on the cellular state is suggested.

TL;DR: This review will focus on the modulation of the interaction between the autophagic protein Beclin 1 and the members of the anti-apoptotic Bcl-2 family and discuss its characteristics, relevance and regulation.