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Eyleen J. O’Rourke

Researcher at University of Virginia

Publications -  34
Citations -  8689

Eyleen J. O’Rourke is an academic researcher from University of Virginia. The author has contributed to research in topics: Autophagy & DNA repair. The author has an hindex of 19, co-authored 34 publications receiving 7050 citations. Previous affiliations of Eyleen J. O’Rourke include Florida State University College of Arts and Sciences & Facultad de Ciencias Exactas y Naturales.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

C. elegans Major Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles

Eyleen J. O’Rourke, +3 more
- 04 Nov 2009 - 
TL;DR: It is shown that the major fat stores are contained in a distinct cellular compartment that is not stained by Nile red, allowing for efficient and accurate genetic and functional genomic screens for genes that control fat accumulation at the organismal level.
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Fat metabolism links germline stem cells and longevity in C. elegans.

Meng C. Wang, +2 more
- 07 Nov 2008 - 
TL;DR: It is found that germline stem cells (GSCs) actively modulate lipid hydrolysis in Caenorhabditis elegans, which in turn regulates longevity, suggesting a link between C. elegans fat metabolism and longevity.
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MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.

Eyleen J. O’Rourke, +1 more
- 01 Jun 2013 - 
TL;DR: MXL-3 and HLH-30 orchestrate an adaptive and conserved cellular response to nutritional status and regulate lifespan in Caenorhabditis elegans and coupling lysosomal lipolysis and autophagy to nutrients is identified.