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Isabella Caniggia

Researcher at Lunenfeld-Tanenbaum Research Institute

Publications -  106
Citations -  12906

Isabella Caniggia is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Trophoblast & Placenta. The author has an hindex of 41, co-authored 101 publications receiving 11095 citations. Previous affiliations of Isabella Caniggia include Mount Sinai Hospital & Health Canada.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

Isabella Caniggia, +6 more
- 01 Mar 2000 - 
TL;DR: Examination of placental expression of hypoxia-inducible factor-1 (HIF-1), a master regulator of oxygen homeostasis, determined that expression of Hif-1alpha subunit during the first trimester of gestation parallels that of TGFbeta(3), an inhibitor of extravillous trophoblast differentiation.
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Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia.

Isabella Caniggia, +3 more
- 01 Mar 2000 - 
TL;DR: It is speculated that if oxygen tension fails to increase, or trophoblasts do not detect this increase, HIF-1alpha and TGFbeta3 expression remain high, resulting in shallow trophoblast invasion and predisposing the pregnancy to pre-eclampsia.
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Molecular Evidence of Placental Hypoxia in Preeclampsia

Nima Soleymanlou, +8 more
- 01 Jul 2005 - 
TL;DR: The results provide molecular evidence that aberrant global placental gene expression changes in preeclampsia may be due to reduced oxygenation and that these events can successfully be mimicked by in vivo and in vitro models of placental hypoxia.