Rui Sheng

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: The results demonstrate that ischemic insult activates autophagy and an autophagic mechanism may contribute to isChemic neuronal injury and may be a potential target for developing a novel therapy for stroke.

TL;DR: It is demonstrated that autophagy activation during IPC offers a remarkable tolerance to a subsequent fatal ischemic insult, and IPC's neuroprotective effects can be mimicked by autophile inducers.

TL;DR: In this review, the possible relationship between lysosome and various neurodegenerative diseases is described and abnormal protein degradation and deposition induced by lysOSomal dysfunction may be the primary contributor to age-related neuro degeneration.