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Stephen E. Girardin

Researcher at University of Toronto

Publications -  204
Citations -  33516

Stephen E. Girardin is an academic researcher from University of Toronto. The author has contributed to research in topics: Innate immune system & NOD2. The author has an hindex of 76, co-authored 192 publications receiving 29535 citations. Previous affiliations of Stephen E. Girardin include Pasteur Institute & French Institute of Health and Medical Research.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.

Stephen E. Girardin, +7 more
- 14 Mar 2003 - 
TL;DR: It is shown here that Nod2 is a general sensor of peptidoglycan through the recognition of muramyl dipeptide (MDP), the minimal bioactive peptIDoglycan motif common to all bacteria.
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Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

Stephen E. Girardin, +14 more
- 06 Jun 2003 - 
TL;DR: It is shown that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine–N-acetelmuramic acid tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-κB pathway.
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Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

Jérôme Viala, +17 more
- 17 Oct 2004 - 
TL;DR: It is proposed that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens as well as an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan.
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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

Leonardo H. Travassos, +16 more
- 01 Jan 2010 - 
TL;DR: The results link bacterial sensing by Nod proteins to the induction of autophagy and provide a functional link between Nod2 and ATG16L1, which are encoded by two of the most important genes associated with Crohn's disease.