Jongsook Kim Kemper

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is reported that SREBP-1c, a key lipogenic activator, is an in vivo target of SIRT1, and acetylation levels were elevated in diet-induced obese mice, and hepatic overexpression of SIRC1 or treatment with resveratrol daily for 1 week decreased acetylated SRE BP- 1c levels with beneficial functional outcomes.

TL;DR: It is reported that FXR is a target of SIRT1, a deacetylase that mediates nutritional and hormonal modulation of hepatic metabolism that reduces acetylated FXR levels and may be a promising therapeutic agents for metabolic disorders.

TL;DR: It is shown that the fed-state sensing nuclear receptor farnesoid X receptor (FXR) and the fasting transcriptional activator cAMP response element-binding protein (CREB) coordinately regulate the hepatic autophagy gene network, resulting in sustained nutrient regulation of autophaky during feeding/fasting cycles.