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Joern Dengjel

Researcher at University of Fribourg

Publications -  49
Citations -  10010

Joern Dengjel is an academic researcher from University of Fribourg. The author has contributed to research in topics: Autophagy & Proteomics. The author has an hindex of 25, co-authored 49 publications receiving 7972 citations. Previous affiliations of Joern Dengjel include University of Freiburg & University of Southern Denmark.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Cardioprotection and lifespan extension by the natural polyamine spermidine

Tobias Eisenberg, +69 more
- 01 Dec 2016 - 
TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.
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mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

Francesca Nazio, +10 more
- 01 Apr 2013 - 
TL;DR: As ULK1 has been shown to activate AMBRA1 by phosphorylation, the proposed pathway may act as a positive regulation loop, which may be targeted in human disorders linked to impaired autophagy.
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AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

Valentina Cianfanelli, +21 more
- 01 Jan 2015 - 
TL;DR: It is shown that the scaffold protein AMBRA1 regulates cell proliferation by facilitating the dephosphorylation and degradation of the proto-oncogene c-Myc and that, when mTOR is inhibited, it enhances PP2A activity on this specific target, thereby reducing the cell division rate.