Massimo Donadelli

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: Findings support a key role of the ROS-dependent activation of an autophagic program in the synergistic growth inhibition induced by GEM/cannabinoid combination in human pancreatic cancer cells.

TL;DR: A potent anti-tumour activity of TSA/GEM combination against pancreatic cancer cells in vitro and in vivo is demonstrated, strongly supporting the use of GEM in combination with an HDAC inhibitor for pancreaticcancer therapy.

TL;DR: Novel findings concerning events that can occur in a concerted manner at various levels of UCP2 regulation are described: Ucp2 gene mutation (single nucleotide polymorphisms), U CP2 mRNA and protein expression (transcriptional, translational, and protein turn-over regulation), UCP1 proton conductance (ligands and post-transcriptionAL modifications), and nutritional and pharmacological regulation of U CP1.