scispace - formally typeset
P

Patrick A. Lewis

Researcher at UCL Institute of Neurology

Publications -  128
Citations -  15086

Patrick A. Lewis is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: LRRK2 & Parkinson's disease. The author has an hindex of 43, co-authored 117 publications receiving 12062 citations. Previous affiliations of Patrick A. Lewis include University College London & Royal Veterinary College.

Papers
More filters
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Mike A. Nalls, +248 more
- 01 Dec 2019 - 
TL;DR: These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.

Elisa Greggio, +17 more
- 01 Aug 2006 - 
TL;DR: Manipulating activity by replacing the kinase domain with a 'kinase-dead' version blocks inclusion body formation and strongly delays cell death, predicting that kinase inhibitors will be useful therapeutic agents in patients with LRRK2 mutations and, perhaps, in sporadic PD.
Journal ArticleDOI

Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences.

Claudia Manzoni, +7 more
- 01 Mar 2018 - 
TL;DR: This review cuts across the boundaries between genomics, transcriptomics and proteomics, summarizing how omics data are generated, analysed and shared and provides an overview of the current strengths and weaknesses of this global approach.