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Scott Zeitlin

Researcher at University of Virginia

Publications -  62
Citations -  13675

Scott Zeitlin is an academic researcher from University of Virginia. The author has contributed to research in topics: Huntingtin & Huntingtin Protein. The author has an hindex of 42, co-authored 59 publications receiving 11286 citations. Previous affiliations of Scott Zeitlin include Columbia University.

Papers
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue.

Scott Zeitlin, +4 more
- 01 Oct 1995 - 
TL;DR: This work proposes that huntingtin is involved in processes counterbalancing the operation of an apoptotic pathway, and shows that this protein is functionally indispensable for nullizygous embryos become developmentally retarded and disorganized, and die between days 8.5 and 10.5 of gestation.
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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice.

Ioannis Dragatsis, +3 more
- 01 Nov 2000 - 
TL;DR: It is proposed that huntingtin is required for neuronal function and survival in the brain and that a loss-of-function mechanism may contribute to HD pathogenesis.
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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.

Eugenia Trushina, +22 more
- 15 Sep 2004 - 
TL;DR: Direct and functional evidence is provided that htt is involved in fast axonal trafficking in mammals and mhtt-mediated aggregation sequesters htt and components of trafficking machinery leading to loss of mitochondrial motility and eventual mitochondrial dysfunction.