Andreas Kern

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: This review focuses on structural and functional alterations of the brain during aging, age-associated imbalances of defences against oxidative stress and age-related alteration of the metabolism of Abeta, via a comparison of observations in healthy aged individuals and cognitively impaired or AD patients.

TL;DR: It is concluded that toxicity of mutant SOD1 is at least partially mediated through heterodimer formation with S OD1(hWT) in vivo and does not correlate with the aggregation potential of individual mutants.

TL;DR: Since aging is accompanied by changes in cellular protein homeostasis and an increasing demand for protein degradation, aspects of protein folding, misfolding, refolding and, importantly, protein degradation need to be linked to AD pathogenesis.