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Nils C. Gassen

Researcher at University of Bonn

Publications -  78
Citations -  9798

Nils C. Gassen is an academic researcher from University of Bonn. The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 26, co-authored 67 publications receiving 7423 citations. Previous affiliations of Nils C. Gassen include University Hospital Bonn & Max Planck Society.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications.

Anthony S. Zannas, +5 more
- 01 Jan 2016 - 
TL;DR: The findings related to FKBP5 illustrate how a deeper understanding of the molecular and systemic mechanisms underlying specific gene–environment interactions may provide insights into the pathogenesis of stress-related disorders.
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Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2.

Markus Hoffmann, +15 more
- 22 Jul 2020 - 
TL;DR: The results indicate that chloroquine targets a pathway for viral activation that is not active in lung cells and is unlikely to protect against the spread of SARS-CoV-2 in and between patients.
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SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Nils C. Gassen, +20 more
- 18 Dec 2019 - 
TL;DR: It is shown that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.