Rut Valdor

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is found that macroautophagy is induced after effector T cell activation, and evidence is presented showing that the nature of the cargo inside autophagic vesicles found in resting T cells differs from the cargo of autophagosomes in activated T cells, where mitochondria and other organelles are selectively excluded.

TL;DR: A role for CMA is defined in regulating T cellactivation through the targeted degradation of negative regulators of T cell activation through the aimed degradation of soluble proteins for lysosomal degradation.

TL;DR: This review focuses on autophagy, a catabolic process that contributes to the maintenance of cellular homeostasis through the degradation of unwanted and damaged components in lysosomes and describes recent advances on the molecular characterization of this process, its different variants and the multiplicity of functions attributed to them.