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Ewout J. Houwerzijl

Researcher at University of Groningen

Publications -  6
Citations -  4672

Ewout J. Houwerzijl is an academic researcher from University of Groningen. The author has contributed to research in topics: Platelet & Thrombopoietin. The author has an hindex of 6, co-authored 6 publications receiving 3751 citations. Previous affiliations of Ewout J. Houwerzijl include University Medical Center Groningen.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura

TL;DR: Most ITP megakaryocytes show ultrastructural features of (para-) apoptosis, probably due to action of factors present in ITP plasma.
Journal ArticleDOI

Increased peripheral platelet destruction and caspase-3–independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients

TL;DR: The results indicate that the main cause of thrombocytopenia in MDS is caspase-3-independent necrosis-like PCD resulting in a decreased PPR in conjunction with an increased glycocalicin index.
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Increased glycocalicin index and normal thrombopoietin levels in patients with idiopathic thrombocytopenic purpura with a decreased rate of platelet production.

TL;DR: Platelet kinetic studies in idiopathic thrombocytopenic purpura have shown that in a subgroup of patients a shortened mean platelet life (MPL) is associated with a decreased platelet production rate (PPR).
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Platelet production rate predicts the response to prednisone therapy in patients with idiopathic thrombocytopenic purpura.

TL;DR: ITP patients with suppressed PPR have a significant higher durable CR/PR rate to prednisone therapy and are less frequently exposed to splenectomy than those with a normal or increased PPR.