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Guanghui Wang

Researcher at Soochow University (Suzhou)

Publications -  208
Citations -  16084

Guanghui Wang is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 41, co-authored 120 publications receiving 13608 citations. Previous affiliations of Guanghui Wang include Royal College of Surgeons in Ireland & University of Science and Technology of China.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

Nihar Ranjan Jana, +3 more
- 01 May 2001 - 
TL;DR: The impaired proteasomal function plays an important role in polyglutamine protein-induced cell death and is associated with disrupted mitochondrial membrane potential, released cytochrome c from mitochondria into the cytosol and activated caspase-9- and caspases-3-like proteases.
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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

Nihar Ranjan Jana, +3 more
- 12 Aug 2000 - 
TL;DR: Overexpression of Hdj-1 and Hsc70 is also able to protect cell death caused by polyglutamine-expanded tNhtt and their combination proved to be most effective and strongly suggests that the chaperone interaction and their redistribution to the aggregates are two completely different phenomena of the cellular unfolded protein response.
Journal ArticleDOI

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

Xiangnan Zhang, +11 more
- 12 Jun 2013 - 
TL;DR: Autophagy was activated in the reperfusion phase, as revealed in both mice with middle cerebral artery occlusion and oxygen-glucose deprived cortical neurons in culture, and the protective role of autophagy during reperfusions may be attributable to mitophagy-related mitochondrial clearance and inhibition of downstream apoptosis.