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Lena F. Burbulla

Researcher at Northwestern University

Publications -  42
Citations -  7106

Lena F. Burbulla is an academic researcher from Northwestern University. The author has contributed to research in topics: Neurodegeneration & Parkinson's disease. The author has an hindex of 20, co-authored 35 publications receiving 5588 citations. Previous affiliations of Lena F. Burbulla include German Center for Neurodegenerative Diseases & University of Tübingen.

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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Lena F. Burbulla, +21 more
- 22 Sep 2017 - 
TL;DR: Dopaminergic neurons derived from patients with idiopathic and familial PD are studied to identify a time-dependent pathological cascade beginning with mitochondrial oxidant stress leading to oxidized dopamine accumulation and ultimately resulting in reduced glucocerebrosidase enzymatic activity, lysosomal dysfunction, and α-synuclein accumulation.
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Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

Peter Reinhardt, +28 more
- 07 Mar 2013 - 
TL;DR: It is shown that multiple PD-associated phenotypes were ameliorated by inhibition of ERK, providing mechanistic insight into the pathogenesis induced by mutant LRRK2 and pointers for the development of potential new therapeutics.
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Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

Chung Han Hsieh, +9 more
- 01 Dec 2016 - 
TL;DR: It is shown that a third PD-related protein, LRRK2, promotes Miro removal by forming a complex with Miro, and this may constitute a central component of PD pathogenesis.
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Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.

Guido Krebiehl, +13 more
- 23 Feb 2010 - 
TL;DR: It is shown that loss of DJ-1 leads to impaired autophagy and accumulation of dysfunctional mitochondria that under physiological conditions would be compensated via lysosomal clearance, providing evidence for a critical role ofDJ-1 in mitochondrial homeostasis in Parkinson's disease.