Ivana Novak

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The hypothesis that ubiquitin represents a selective degradation signal suitable for targeting various types of cargo, ranging from protein aggregates to membrane-bound organelles and microbes, is explored.

TL;DR: Nix functions as an autophagy receptor, which mediates mitochondrial clearance after mitochondrial damage and during erythrocyte differentiation, and ablation of the Nix:LC3/GABARAP interaction retards mitochondrial clearance in maturing murine reticulocytes.

TL;DR: It is demonstrated that enhancing Bnip3-Atg8 interactions via phosphorylation-mimicked LIR mutations increased mitochondrial sequestration, lysosomal delivery, and degradation, and Importantly, mitochondria were targeted by mitophagy prior to cytochrome c release, resulting in reduced cellular cytochrom c release capacity.

TL;DR: Two new proteins, SYCE1 and CESC1, interact with the transverse filament protein SYCP1, and their localisation to the central element of the mammalian synaptonemal complex appears to depend on recruitment bySYCP1.