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Jonathan P. Butchar

Researcher at Ohio State University

Publications -  59
Citations -  6879

Jonathan P. Butchar is an academic researcher from Ohio State University. The author has contributed to research in topics: Francisella & Monocyte. The author has an hindex of 27, co-authored 57 publications receiving 5715 citations. Previous affiliations of Jonathan P. Butchar include The Ohio State University Wexner Medical Center.

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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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miR-155 regulates IFN-γ production in natural killer cells.

Rossana Trotta, +10 more
- 12 Apr 2012 - 
TL;DR: It is indicated that miR-155 expression is regulated by stimuli that strongly induce IFN-γ in NK cells such as IL-12, IL-18, and CD16 activation, and that mi R-155 functions as a positive regulator of IFn-γ production in human NK cells, at least in part via down-regulating SHIP1.
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Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

Anwari Akhter, +14 more
- 03 Apr 2009 - 
TL;DR: Using the intracellular pathogen L. pneumophila, it is shown that, upon infection of murine macrophages, caspase-7 was activated downstream of the Nlrc4 inflammasome and required casp enzyme-1 activation, and a novel biological role for caspasing-7 in host defense against an intrACEllular bacterium is presented.
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Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains.

Michael C Sweeney, +5 more
- 15 Nov 2005 - 
TL;DR: A general, combinatorial library method for the rapid identification of high-affinity peptide ligands of protein modular domains is reported and it is suggested that the four classes of pY peptides all bind to the same site on the SH2 domain surface.
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MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response.

Thomas J. Cremer, +11 more
- 30 Dec 2009 - 
TL;DR: It is shown that SHIP expression is strongly down-regulated in monocytes and macrophages following infection with F. tularensis novicida, and impaired miR-155 induction by SCHU S4 may help explain the lack of both SHIP down-regulation and pro-inflammatory response and may account for the virulence of Type A Francisella.