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Laurent Le Cam

Researcher at University of Montpellier

Publications -  31
Citations -  10200

Laurent Le Cam is an academic researcher from University of Montpellier. The author has contributed to research in topics: Cancer & Myeloid leukemia. The author has an hindex of 11, co-authored 27 publications receiving 8626 citations. Previous affiliations of Laurent Le Cam include French Institute of Health and Medical Research & Centre national de la recherche scientifique.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

Matthieu Lacroix, +4 more
- 01 Mar 2020 - 
TL;DR: An overview of the current knowledge on the metabolic activities of wild type (WT) p53 is provided and some of the mechanisms by which p53 contributes to whole body energy homeostasis are highlighted to pinpoint some evidences suggesting that deregulation of p53-associated metabolic activities leads to human pathologies beyond cancer.
Journal Article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2459 more
- 01 Jan 2016 - 
Journal ArticleDOI

Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia

Héléna Boutzen, +47 more
- 04 Apr 2016 - 
TL;DR: It is shown that the IDH1 mutation and its oncometabolite, (R)-2-hydroxyglutarate, dysregulate downstream target pathways of myeloid-specific TFs, especially CEBPα, priming mutant IDH 1-R132H AML blasts to the granulomonocytic lineage.