Eiichiro Nagata

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: A small molecule SC79 is identified that inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol, resulting in augmented neuronal survival in a hippocampal neuronal culture system and a mouse model for ischemic stroke.

TL;DR: In intact adult brain cerebral cortex of HO-2–null mice, imaging mass spectrometry reveals an impaired ability to maintain ATP levels on hypoxia, and a pathway mediating Hypoxia-induced cerebral vasodilation is reported.

TL;DR: This ELISA combined with determination of the IgG4 subclass is useful in screening for anti-NF155 antibodies, which were confirmed by western blot, cell-based assay and immunohistochemical study.

TL;DR: The findings indicate that the TRPV1 receptor in the dura mater and sensory ganglia may contribute to the pathophysiology of migraine, providing an important clue for the development of therapeutic strategies for migraine.