Lester M. Davids

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This in vitro study analyses the phototoxic effect of UVA - activated hypericin in human pigmented and unpigmented melanomas and immortalised keratinocytes and melanocytes and suggests that UVA is effective in activatinghypericin and that this phototoxicity may be considered as treatment option in some cases of lentigomaligna or lentigo maligna melanoma that are too large for surgical resection.

TL;DR: Hypericin-PDT was effective in killing both unpigmented and pigmented melanoma cells by specific mechanisms involving the externalization of phosphatidylserines, cell shrinkage and loss of cell membrane integrity as well as a caspase-independent apoptotic mode that did not involve apoptosis-inducing factor (501 mel).

TL;DR: Results show that extracts of honeybush and to some extent, hesperidin and mangiferin, renders protection against UVB-induced skin damage.