Gyesoon Yoon

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this paper, the authors confirm a link between mitochondrial dysfunction and type 2 diabetes, and propose a method to confirm the link between mitochondria dysfunction and Type 2 diabetes using a blood test.

TL;DR: Results indicate that different doses of doxorubicin activate different regulatory mechanisms to induce either apoptosis or cell death through mitotic catastrophe.

TL;DR: It is shown that the fed-state sensing nuclear receptor farnesoid X receptor (FXR) and the fasting transcriptional activator cAMP response element-binding protein (CREB) coordinately regulate the hepatic autophagy gene network, resulting in sustained nutrient regulation of autophaky during feeding/fasting cycles.

TL;DR: It was found that direct induction of mitochondrial elongation by blocking mitochondrial fission process with Fis1‐ΔTM or Drp1‐K38A was sufficient to develop senescent phenotypes with increased ROS production, suggesting that mitochondria elongation may play an important role as a mediator in stress‐induced premature senescence.