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Maciej S. Lesniak

Researcher at Northwestern University

Publications -  303
Citations -  17973

Maciej S. Lesniak is an academic researcher from Northwestern University. The author has contributed to research in topics: Glioma & Oncolytic virus. The author has an hindex of 56, co-authored 271 publications receiving 14773 citations. Previous affiliations of Maciej S. Lesniak include City of Hope National Medical Center & University of Illinois at Chicago.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction

Dong-Hyun Kim, +6 more
- 01 Feb 2010 - 
TL;DR: In this paper, a spin-vortex ground state oscillates when activated by an alternating magnetic field, compromising the integrity of the cell membrane and initiating programmed cell death in ∼90% of cancer cells in vitro, even with a low-frequency field applied for only ten minutes.
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Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

Derek A. Wainwright, +11 more
- 15 Oct 2014 - 
TL;DR: The therapeutic inhibition of IDO, CTLA-4, and PD-L1 in a mouse model of well-established glioma maximally decreases tumor-infiltrating Tregs, coincident with a significant increase in T-cell–mediated long-term survival.
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CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

Alan L. Chang, +15 more
- 01 Oct 2016 - 
TL;DR: It is reported that macrophages and microglia within the glioma microenvironment produce CCL2, a chemokine that is critical for recruiting both CCR4+ Treg and CCR2+Ly-6C+ monocytic MDSCs in this disease setting.
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IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival

Derek A. Wainwright, +8 more
- 15 Nov 2012 - 
TL;DR: Clinical and preclinical data confirm that IDO expression increases the recruitment of immunosuppressive Tregs that lead to tumor outgrowth, and IDO deficiency decreases Treg recruitment and enhances T-cell–mediated tumor rejection.