Clelia Miracco

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In most high-grade astrocytic, ependymal neoplasms and atypical meningiomas the authors found a decrease of cytoplasmic protein expression that was, instead, high in the majority of low-grade tumours and in medulloblastomas, which further support its involvement also in brain tumours.

TL;DR: Three patients with advanced melanoma, who experienced progressive disease after a variety of previous therapies, including prior immunotherapies, and who achieved good outcomes with ipilimumab are reported on, highlighting the potential for anti-CTLA-4-based therapy in previously treated patients withadvanced melanoma.

TL;DR: A digital dermoscopy analyzer is used to evaluate a series of 588 excised, clinically atypical, flat pigmented skin lesions and the good diagnostic performance and high speed in reading and analyzing lesions (real time) of this method constitute an important step in the direction of automated diagnosis of pigmentedskin lesions.

TL;DR: The study of the role of miR-17 in regulating ATG7 expression and autophagy reveals a novel function for this miRNA sequence in a critical cellular event with significant impacts in cancer development, progression and treatment.