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Zhen Lu

Researcher at University of Texas MD Anderson Cancer Center

Publications -  82
Citations -  7546

Zhen Lu is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Ovarian cancer & Autophagy. The author has an hindex of 30, co-authored 82 publications receiving 6127 citations. Previous affiliations of Zhen Lu include University of Texas at Austin & Harvard University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells

Zhen Lu, +11 more
- 01 Dec 2008 - 
TL;DR: It is shown that re-expression of ARHI in multiple human ovarian cancer cell lines induces autophagy by blocking PI3K signaling and inhibiting mammalian target of rapamycin (mTOR), upregulating ATG4, and colocalizing with cleaved microtubule-associated protein light chain 3 (LC3) in autophagosomes.
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Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus

Richard G. Moore, +8 more
- 01 Aug 2008 - 
TL;DR: HE4 is elevated in all stages of endometrial can100cer and is more sensitive in early-stageendometrial cancer compared to CA125, and further investigation of HE4 as a marker for early detection of recurrent endometrioid adenocarcinoma of the uterus is warranted.
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Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation.

Weiwei Feng, +8 more
- 01 Apr 2008 - 
TL;DR: Two imprinted genes, paternally expressed 3 (PEG3) and aplasia Ras homologue member I (ARHI), are the most frequently down‐regulated in ovarian cancers on gene expression arrays.
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SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.

Ahmed Ashour Ahmed, +18 more
- 17 Aug 2010 - 
TL;DR: It is shown that the salt inducible kinase 2 (SIK2) plays a key role in the initiation of mitosis, and regulates the localization of the centrosome linker protein, C-Nap1, through S2392 phosphorylation, which identifies SIK2 as a plausible target for therapy in ovarian cancers.