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Yoshitaka Isaka

Researcher at Osaka University

Publications -  424
Citations -  23370

Yoshitaka Isaka is an academic researcher from Osaka University. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 56, co-authored 379 publications receiving 19611 citations. Previous affiliations of Yoshitaka Isaka include University of Utah & Toray Industries.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

Yoshitaka Isaka, +5 more
- 01 Dec 1993 - 
TL;DR: Using an in vivo transfection technique, the selective overexpression of single growth factor in the kidney is realized and the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former.
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Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney

Yoshitaka Isaka, +6 more
- 01 Apr 1996 - 
TL;DR: Transfected glomerulonephritic rats showed a significant reduction in levels of glomerular TGF–β1 mRNA and TGF-β1 protein, extracellular matrix accumulation and proteinuria, demonstrating the potential of gene therapy as a novel treatment for fibrotic diseases caused by TGF –β1.
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Chloroquine in cancer therapy: a double-edged sword of autophagy.

Tomonori Kimura, +3 more
- 01 Jan 2013 - 
TL;DR: The functions of autophagy in cancer and kidney injury are summarized, especially focusing on the use of chloroquine to treat cancer, and the possible side effects are addressed in the combined use ofchloroquine and anticancer drugs.