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Shyamal D. Desai

Researcher at LSU Health Sciences Center New Orleans

Publications -  38
Citations -  7105

Shyamal D. Desai is an academic researcher from LSU Health Sciences Center New Orleans. The author has contributed to research in topics: Topoisomerase & DNA damage. The author has an hindex of 21, co-authored 35 publications receiving 5952 citations. Previous affiliations of Shyamal D. Desai include Rutgers University & University of Medicine and Dentistry of New Jersey.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Mechanism of action of camptothecin

Leroy F. Liu, +5 more
- 01 Dec 1996 - 
TL;DR: Camptothecin class of compounds has been demonstrated to be effective against a broad spectrum of tumors and two novel repair responses to topo‐I‐mediated DNA damage involving covalent modifications of topo-I have been discovered.
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Ubiquitin-dependent Destruction of Topoisomerase I Is Stimulated by the Antitumor Drug Camptothecin

Shyamal D. Desai, +3 more
- 26 Sep 1997 - 
TL;DR: It is demonstrated that independent of DNA replication, the TOP1 cleavable complex is ubiquitinated and destroyed in cells treated with antitumor drugs that block the religation step of the Topoisomerase I reaction.
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SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

Yong Mao, +3 more
- 11 Apr 2000 - 
TL;DR: Treatment of mammalian cells or yeast cells expressing human DNA TOP1 with camptothecin (CPT) induces covalent modification of the TOP1 by SUMO-1/Smt3p, a ubiquitin-like protein.
Journal Article

Ubiquitin/26S Proteasome-mediated Degradation of Topoisomerase I As a Resistance Mechanism to Camptothecin in Tumor Cells

Shyamal D. Desai, +4 more
- 01 Aug 2001 - 
TL;DR: The results suggest that CPT-induced down-regulation of TOP1 could be an important parameter for determining CPT sensitivity/resistance in tumor cells.